Human sperm mutations that can cause disease in children identified

Throughout development, life and the processes of aging, all human cells accumulate mutations, resulting in what is called mosaicism, a condition in which different cells in the same person have different DNA sequences or genetic makeup. Mosaicism occurs in every human but is mostly unnoticeable. If abnormal cells begin to outnumber normal cells, however, diseases […]

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Scientists show how blocking opioid receptors in specific neurons can restore breathing during an overdose

It’s long been known that opioid overdose deaths are caused by disrupted breathing, but the actual mechanism by which these drugs suppress respiration was not understood. Now, a new study by Salk scientists has identified a group of neurons in the brainstem that plays a key role in this process. The findings, published June 8 […]

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Researchers pinpoint how PARP inhibitors combat BRCA1 and BRCA2 tumor cells

A team of Massachusetts General Hospital (MGH) researchers has discovered how an important class of anti-cancer drugs called PARP inhibitors works, a finding that could help improve treatment and prolong survival for patients with breast cancer and other malignancies. PARP (poly[ADP-ribose] polymerase) inhibitors such as olaparib (Lynparza), rucaparib (Rubraca) and niraparib (Zejula) are used to […]

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